Our latest puplication https://www.mdpi.com/2306-5354/12/1/15 explores the full electroretinogram data set to see if it is possible to classify individuals with ASD or ADHD or ASD + ADHD from typivally developing participants.
In a series of ERGs collected in ASD (n = 77), ADHD (n = 43), ASD + ADHD (n = 21), and control (n = 137) groups, this analysis explores the use of machine learning and feature selection techniques to improve the classification between these clinically defined groups. Standard time domain and signal analysis features were evaluated in different machine learning models. For ASD classification, a balanced accuracy (BA) of 0.87 was achieved for male participants. For ADHD, a BA of 0.84 was achieved for female participants. When a three-group model (ASD, ADHD, and control) the BA was lower, at 0.70, and fell further to 0.53 when all groups were included (ASD, ADHD, ASD + ADHD, and control). The findings support a role for the ERG in establishing a broad two-group classification of ASD or ADHD, but the model’s performance depends upon sex and is limited when multiple classes are included in machine learning modeling.
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